Article
Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis.
Cells, tissues, organs - 1 Jan 2011
Sun Yao, Chen Li, Ma Su, Zhou Jin, Zhang Hua, Feng Jian Q, Qin Chunlin
Abstract excerpt
Dentin matrix protein 1 (DMP1) is an acidic protein that plays critical roles in osteogenesis and dentinogenesis. Protein chemistry studies have demonstrated that DMP1 primarily exists as processed NH₂⁻ and COOH-terminal fragments in the extracellular matrix of bone and dentin. Our earlier work showed that the substitution of Asp²¹³ (a residue at a cleavage site) by Ala²¹³ blocks the processing of mouse DMP1 in...
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