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Article

Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice.

International journal of oral science - 1 Sept 2014

Lin Shu-Xian, Zhang Qi, Zhang Hua, Yan Kevin, Ward Leanne, Lu Yong-Bo, Feng Jian-Quan

Abstract excerpt

Dentin matrix protein 1 (DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment. Primarily, DMP1 is considered as an extracellular matrix protein that promotes hydroxyapatite formation and activates intracellular signaling pathway via interacting with αvβ3 integrin. Recent in vitro studies suggested...

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Source

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Identifiers

PMID: 25105818
DOI: 10.1038/ijos.2014.44
PMCID: PMC4170153

Genes

DMP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice.PMID 25105818Read ↗

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