Article
Variation in base excision repair capacity.
Mutation research - 3 Jun 2011
Wilson David M, Kim Daemyung, Berquist Brian R, Sigurdson Alice J
Abstract excerpt
The major DNA repair pathway for coping with spontaneous forms of DNA damage, such as natural hydrolytic products or oxidative lesions, is base excision repair (BER). In particular, BER processes mutagenic and cytotoxic DNA lesions such as non-bulky base modifications, abasic sites, and a range of chemically distinct single-strand breaks. Defects in BER have been linked to cancer predisposition, neurodegenerative...
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