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Article

DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions.

Nucleic acids research - 1 Jan 2007

Parsons Jason L, Preston Bradley D, O'Connor Timothy R, Dianov Grigory L

Abstract excerpt

Base excision repair (BER) is the major pathway for the repair of simple, non-bulky lesions in DNA that is initiated by a damage-specific DNA glycosylase. Several human DNA glycosylases exist that efficiently excise numerous types of lesions, although the close proximity of a single strand break (SSB) to a DNA adduct can have a profound effect on both BER and SSB repair. We recently reported that DNA lesions...

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Identifiers

PMID: 17264132
DOI: 10.1093/nar/gkl1115
PMCID: PMC1851633

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