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Article

Base excision repair fidelity in normal and cancer cells.

Mutagenesis - 1 May 2006

Chan Katie K L, Zhang Qiu-Mei, Dianov Grigory L

Abstract excerpt

In mammalian cells, base excision repair (BER) is the major repair pathway involved in the removal of non-bulky damaged nucleotides. The fidelity of BER is dependent on the polymerization step, where the major BER DNA polymerase (Pol beta) must incorporate the correct Watson-Crick base paired nucleotide into the one nucleotide repair gap. Recent studies have indicated that expression of some Pol beta variants or...

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Identifiers

PMID: 16613912
DOI: 10.1093/mutage/gel020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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