A New Approach to the Inhibition of Metallo‐β‐lactamases

Abstract excerpt

Plan of attack: β-Lactam antibiotics remain at the forefront of the battle with pathogenic bacteria, particularly of Gram-negative strains that cause hospital-acquired infections. Metallo-β-lactamases, enzymes that confer resistance to almost all β-lactams, are spreading in these organisms. A new class of irreversible metallo-β-lactamase inhibitor (OPS; see picture) offers hope for the development of...

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