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Article

The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2005

Kim Myung Hee, Choi Won-Chan, Kang Hye Ok, Lee Jong Suk, Kang Beom Sik, Kim Kyung-Jin, Derewenda Zygmunt S, Oh Tae-Kwang, Lee Choong Hwan, Lee Jung-Kee

Abstract excerpt

In many Gram-negative bacteria, including a number of pathogens such as Pseudomonas aeruginosa and Erwinia carotovora, virulence factor production and biofilm formation are linked to the quorum-sensing systems that use diffusible N-acyl-L-homoserine lactones (AHLs) as intercellular messenger molecules. A number of organisms also contain genes coding for lactonases that hydrolyze AHLs into inactive products,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16314577
DOI: 10.1073/pnas.0504996102
PMCID: PMC1295591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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