A designed supramolecular protein assembly with in vivo enzymatic activity.

Abstract excerpt

The generation of new enzymatic activities has mainly relied on repurposing the interiors of preexisting protein folds because of the challenge in designing functional, three-dimensional protein structures from first principles. Here we report an artificial metallo-β-lactamase, constructed via th...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ampicillin
• Share to beta-Lactamases
• Share to Directed Molecular Evolution