Article
Two alleles of a neural protein gene linked to scrapie in sheep.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Goldmann W, Hunter N, Foster J D, Salbaum J M, Beyreuther K, Hope J
Abstract excerpt
Sheep are the natural hosts of the pathogens that cause scrapie, an infectious degenerative disease of the central nervous system. Scrapie-associated fibrils [and their major protein, prion protein (PrP)] accumulate in the brains of all species affected by scrapie and related diseases. PrP is encoded by a single gene that is linked to (and may be) the major gene controlling the incubation period of the various...
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