Two alleles of a neural protein gene linked to scrapie in sheep.

doi:10.1073/pnas.87.7.2476

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Article

Two alleles of a neural protein gene linked to scrapie in sheep.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990

Goldmann W, Hunter N, Foster J D, Salbaum J M, Beyreuther K, Hope J

Abstract excerpt

Sheep are the natural hosts of the pathogens that cause scrapie, an infectious degenerative disease of the central nervous system. Scrapie-associated fibrils [and their major protein, prion protein (PrP)] accumulate in the brains of all species affected by scrapie and related diseases. PrP is encoded by a single gene that is linked to (and may be) the major gene controlling the incubation period of the various...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Exons
Gene Library
Genes
Genes, Viral
Introns
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

PrPSc Proteins

Prions

RNA, Messenger

Restriction Mapping

Sequence Homology, Nucleic Acid

Sheep

Source

Open in PubMed Open full text

Identifiers

PMID: 1969635
DOI: 10.1073/pnas.87.7.2476
PMCID: PMC53712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1969635-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Two alleles of a neural protein gene linked to scrapie in sheep.PMID 1969635Read ↗

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