Experimental transmission of sheep scrapie by intracerebral and oral routes to genetically susceptible Suffolk sheep in the United States.

doi:10.1177/104063870501700103

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Article

Experimental transmission of sheep scrapie by intracerebral and oral routes to genetically susceptible Suffolk sheep in the United States.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc - 1 Jan 2005

Hamir Amir N, Kunkle Robert A, Richt Juergen A, Miller Janice M, Cutlip Randall C, Jenny Allen L

Abstract excerpt

Scrapie is a naturally occurring fatal neurodegenerative disease of sheep and goats. Susceptibility to the disease is partly dependent on the genetic makeup of the host. This study documents clinicopathological findings and the distribution of abnormal prion proteins (PrPres) by immunohistochemical and Western blot techniques, in tissues of genetically susceptible sheep inoculated with US sheep scrapie agents....

Topics

Administration, Oral
Animals
Brain
Female
Genetic Predisposition to Disease
Injections
Lymph Nodes
Male
Prions
Scrapie
Sheep
United States

Source

Open in PubMed

Identifiers

PMID: 15690944
DOI: 10.1177/104063870501700103

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