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Article

Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Aug 2005

Lai I-C, Wang Y-C, Lin C-C, Bai Y-M, Liao D-L, Yu S-C, Lin C-Y, Chen J-Y, Liou Y-J

Abstract excerpt

Chronic administration of typical antipsychotic agents, which mainly act on the dopamine receptors, implicates a role of dopamine system on the susceptibility of tardive dyskinesia (TD). In the present study, the association between a functional Val158Met polymorphism of Catechol-O-methyltransferase (COMT) gene and TD occurrence and TD severity was investigated in 299 Chinese schizophrenic patients with long-term...

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Source

Identifiers

PMID: 15583953
DOI: 10.1007/s00702-004-0252-6

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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