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Article

Relationship between catechol‐<i>O</i>‐methyltransferase polymorphism and treatment‐resistant schizophrenia

11 Jun 2003

Abstract excerpt

Catechol-O-methyltransferase (COMT) plays a crucial role in the regulation of central dopaminergic systems. We examined the allelic association of a functional polymorphism of the COMT gene with the clinical manifestations and the response to antipsychotics of 100 schizophrenic patients and 201 healthy controls from the general Japanese population. No statistically significant difference was observed in the...

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PMID: 12815736
DOI: 10.1002/ajmg.b.20023

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