Article
Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones.
Journal of surgical oncology - 1 Dec 2007
Tanaka Junichiro, Watanabe Toshiaki, Kanazawa Takamitsu, Tada Tomohiro, Kazama Yoshihiro, Tanaka Toshiaki, Nagawa Hirokazu
Abstract excerpt
CONDENSED ABSTRACT: We compared the methylation status of several loci between right-sided and left-sided colorectal cancers (CRCs). To the best of our knowledge, this is the first to report that left-sided CRCs show significantly less frequent methylation at several loci and CpG island methylator phenotype (CIMP) than right-sided ones. BACKGROUND AND OBJECTIVES: MSI CRC occurs in 10-20% of unselected series of...
Topics
- Adaptor Proteins, Signal Transducing
- Adult
- Aged
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- MutL Protein Homolog 1
- Nuclear Proteins
- Phenotype