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Article

Microsatellite instability in gastric cancer is closely associated with hMLH1 hypermethylation at the proximal region of the promoter.

International journal of molecular medicine - 1 Oct 2003

Ishiguro Kaname, Kawakami Kazuyuki, Maeda Kazuya, Ishida Yoshinori, Omura Kenji, Watanabe Go

Abstract excerpt

Most sporadic gastric cancer with the microsatellite instability (MSI) phenotype is linked with hypermethylation (HM) of hMLH1. However, a part of gastric cancer with hMLH1 HM does not show MSI, suggesting a region-specific effect of hMLH1 promoter methylation on developing MSI. To test this possibility, we measured the methylation level in 3 distinct areas of hMLH1 promoter and compared them with MSI in 129...

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PMID: 12964042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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