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Article

A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease.

Nature medicine - 1 Aug 2008

Li Xiaogang, Magenheimer Brenda S, Xia Sheng, Johnson Teri, Wallace Darren P, Calvet James P, Li Rong

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by heterozygous mutations in either PKD1 or PKD2, genes that encode polycystin-1 and polycystin-2, respectively. We show here that tumor necrosis factor-alpha (TNF-alpha), an inflammatory cytokine present in the cystic fluid of humans with ADPKD, disrupts the localization of polycystin-2 to the plasma membrane and primary cilia through a scaffold...

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Source

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Identifiers

PMID: 18552856
DOI: 10.1038/nm1783
PMCID: PMC3359869

Genes

TNF
PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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