Selective breeding for differential saccharin intake as an animal model of drug abuse.

doi:10.1097/FBP.0b013e32830c3632

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Article

Selective breeding for differential saccharin intake as an animal model of drug abuse.

Behavioural pharmacology - 1 Sept 2008

Carroll Marilyn E, Morgan Andrew D, Anker Justin J, Perry Jennifer L, Dess Nancy K

Abstract excerpt

A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence from behavioral, neurobiological, and linkage studies in heterogeneous and homogeneous animal populations. Initial work in several laboratories...

Topics

Alcoholism
Animals
Arousal
Disease Models, Animal
Female
Genotype
Male
Mice
Mice, Inbred Strains
Motivation
Phenotype
Rats
Rats, Inbred Strains
Saccharin
Selection, Genetic
Self Administration
Sex Factors
Substance-Related Disorders

Source

Open in PubMed

Identifiers

PMID: 18690102
DOI: 10.1097/FBP.0b013e32830c3632

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