Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

doi:10.1016/j.pbb.2012.07.007

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Article

Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

Pharmacology, biochemistry, and behavior - 1 Nov 2012

Bell Richard L, Sable Helen J K, Colombo Giancarlo, Hyytia Petri, Rodd Zachary A, Lumeng Lawrence

Abstract excerpt

The purpose of this review paper is to present evidence that rat animal models of alcoholism provide an ideal platform for developing and screening medications that target alcohol abuse and dependence. The focus is on the 5 oldest international rat lines that have been selectively bred for a high alcohol-consumption phenotype. The behavioral and neurochemical phenotypes of these rat lines are reviewed and placed...

Topics

Alcohol Drinking
Alcoholism
Animals
Behavior, Animal
Brain
Breeding
Disease Models, Animal
Female
Humans
Male
Neurotransmitter Agents
Phenotype
Rats
Rats, Inbred Strains

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Receptors, Neurotransmitter

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Identifiers

PMID: 22841890
DOI: 10.1016/j.pbb.2012.07.007
PMCID: PMC3595005

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