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Article

Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer.

Gynecologic oncology - 1 Dec 2004

Cvetkovic Dusica, Pisarcik Debra, Lee Chan, Hamilton Thomas C, Abdollahi Abbas

Abstract excerpt

OBJECTIVES: Previously, we demonstrated that the LOT1 (PLAGL1/ZAC1) gene encodes a zinc-finger transcription factor and has growth suppressive effects in carcinoma cell lines. The gene is localized on chromosome 6q24-25, a common site for loss of heterozygosity (LOH) in many solid tumors including ovarian cancer. In this study, we evaluated the LOT1 gene expression and allelic deletion in the tumor tissues in...

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Source

Identifiers

PMID: 15581945
DOI: 10.1016/j.ygyno.2004.08.051

Genes

PLAGL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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