Article
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary.
Cancer genetics - 1 Nov 2011
Geiersbach Katherine B, Jarboe Elke A, Jahromi Mona S, Baker Christine L, Paxton Christian N, Tripp Sheryl R, Schiffman Joshua D
Abstract excerpt
Adult granulosa cell tumors (AGCTs) are a rare class of ovarian tumors with recurrent cytogenetic abnormalities including trisomy 12, trisomy 14, monosomy 16/deletion 16q, and monosomy 22. Over 90% contain a missense point mutation (C134W) in the FOXL2 gene at 3q22.3. The relationship between FOXL2 mutation and cytogenetic abnormalities is unclear, although both are presumably early events in tumorigenesis. In...
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