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Article

Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas.

Cancer genetics - 1 Jul 2011

Jarmalaite Sonata, Laurinaviciene Aida, Tverkuviene Justina, Kalinauskaite Neringa, Petroska Donatas, Böhling Tom, Husgafvel-Pursiainen Kirsti

Abstract excerpt

ZAC/PLAGL1 is a novel imprinted tumor suppressor gene encoding an important inducer of cell cycle arrest and apoptosis, and found to be lost during tumorigenesis. We analyzed the significance of ZAC in the development of a rare, usually benign tumor of the adrenal gland: pheochromocytoma (PCC). T...

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Source

Identifiers

PMID: 21872827
DOI: 10.1016/j.cancergen.2011.07.002

Genes

PLAGL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21872827-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas.PMID 21872827Read ↗

Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.Semantic proximity Read ↗

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene networkSemantic proximity Read ↗

Preferential loss of the nonimprinted allele for the ZAC1 tumor suppressor gene in human capillary hemangioblastoma.Semantic proximity Read ↗

The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.Semantic proximity Read ↗

The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetesSemantic proximity Read ↗

Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.Semantic proximity Read ↗

LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functionsSemantic proximity Read ↗

Frequent loss of heterozygosity at 6q in pheochromocytoma.Semantic proximity Read ↗

<i>Zac1</i> (<i>Lot1</i>), a Potential Tumor Suppressor Gene, and the Gene for ɛ-Sarcoglycan Are Maternally Imprinted Genes: Identification by a Subtractive Screen of Novel Uniparental Fibroblast LinesSemantic proximity Read ↗

Members of the <i>Plag</i> gene family are expressed in complementary and overlapping regions in the developing murine nervous systemSemantic proximity Read ↗

Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic GrowthSemantic proximity Read ↗

Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.Semantic proximity Read ↗

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