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Article

LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.

The Journal of biological chemistry - 21 Feb 2003

Abdollahi Abbas, Pisarcik Debra, Roberts David, Weinstein Jillian, Cairns Paul, Hamilton Thomas C

Abstract excerpt

LOT1 is a zinc-finger nuclear transcription factor, which possesses anti-proliferative effects and is frequently silenced in ovarian and breast cancer cells. The LOT1 gene is localized at chromosome 6q24-25, a chromosomal region maternally imprinted and linked to growth retardation in several organs and progression of disease states such as transient neonatal diabetes mellitus. Toward understanding the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12473647
DOI: 10.1074/jbc.M210361200

Genes

PLAGL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.PMID 12473647Read ↗

Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer.Semantic proximity Read ↗

LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functionsSemantic proximity Read ↗

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene networkSemantic proximity Read ↗

<i>Zac1</i> (<i>Lot1</i>), a Potential Tumor Suppressor Gene, and the Gene for ɛ-Sarcoglycan Are Maternally Imprinted Genes: Identification by a Subtractive Screen of Novel Uniparental Fibroblast LinesSemantic proximity Read ↗

LOT1 (ZAC1/PLAGL1) as member of an imprinted gene network does not harbor Silver-Russell specific variants.Semantic proximity Read ↗

The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice.Semantic proximity Read ↗

Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.Semantic proximity Read ↗

A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC.Semantic proximity Read ↗

The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetesSemantic proximity Read ↗

Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancerSemantic proximity Read ↗

Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic GrowthSemantic proximity Read ↗

Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.Semantic proximity Read ↗

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