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Article

The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways.

Molecular biology of the cell - 1 Jul 2008

Cheung Herman H, Plenchette Stéphanie, Kern Chris J, Mahoney Douglas J, Korneluk Robert G

Abstract excerpt

The Inhibitor of Apoptosis proteins (IAPs) are key repressors of apoptosis. Several IAP proteins contain a RING domain that functions as an E3 ubiquitin ligase involved in the ubiquitin-proteasome pathway. Here we investigated the interplay of ubiquitin-proteasome pathway and RING-mediated IAP turnover. We found that the CARD-RING domain of cIAP1 (cIAP1-CR) is capable of down-regulating protein levels of...

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Identifiers

PMID: 18434593
DOI: 10.1091/mbc.e08-01-0107
PMCID: PMC2441678

Genes

XIAP
NAIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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