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Recent advances in understanding inhibitor of apoptosis proteins

3 Dec 2018

Abstract excerpt

The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis by blocking caspase activation or activity. Recent research has shown that cellular IAP1 (cIAP1), cIAP2, and X-linked IAP (XIAP) also regulate signaling by receptors of the innate immune system by ubiquitylating their substrates. These IAPs thereby act at the intersection of pathways...

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PMID: 30631429
DOI: 10.12688/f1000research.16439.1

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