Article
Experimental adaptation of Salmonella typhimurium to mice.
Genetics - 1 Nov 2004
Nilsson Annika I, Kugelberg Elisabeth, Berg Otto G, Andersson Dan I
Abstract excerpt
Experimental evolution is a powerful approach to study the dynamics and mechanisms of bacterial niche specialization. By serial passage in mice, we evolved 18 independent lineages of Salmonella typhimurium LT2 and examined the rate and extent of adaptation to a mainly reticuloendothelial host environment. Bacterial mutation rates and population sizes were varied by using wild-type and DNA repair-defective mutator...
Topics
- Adaptation, Physiological
- Animals
- Data Interpretation, Statistical
- Evolution, Molecular
- Kinetics
- Mice
- Models, Genetic
- Mutation
- Salmonella Infections
- Salmonella typhimurium