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Article

Experimental adaptation of Salmonella typhimurium to mice.

Genetics - 1 Nov 2004

Nilsson Annika I, Kugelberg Elisabeth, Berg Otto G, Andersson Dan I

Abstract excerpt

Experimental evolution is a powerful approach to study the dynamics and mechanisms of bacterial niche specialization. By serial passage in mice, we evolved 18 independent lineages of Salmonella typhimurium LT2 and examined the rate and extent of adaptation to a mainly reticuloendothelial host environment. Bacterial mutation rates and population sizes were varied by using wild-type and DNA repair-defective mutator...

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Identifiers

PMID: 15579674
DOI: 10.1534/genetics.104.030304
PMCID: PMC1448776

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Source receipt: pubmed, retrieved 7 Sept 2026.

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