Article
Role of mutator alleles in adaptive evolution.
Nature - 12 Jun 1997
Taddei F, Radman M, Maynard-Smith J, Toupance B, Gouyon P H, Godelle B
Abstract excerpt
Because most newly arising mutations are neutral or deleterious, it has been argued that the mutation rate has evolved to be as low as possible, limited only by the cost of error-avoidance and error-correction mechanisms. But up to one per cent of natural bacterial isolates are 'mutator' clones t...
Topics
- Adaptation, Physiological
- Alleles
- Animals
- Directed Molecular Evolution
- Escherichia coli
- Evolution, Molecular
- Mammals
- Models, Biological
- Mutation
- Selection, Genetic