Article
Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance.
Science (New York, N.Y.) - 25 Feb 2000
Björkman J, Nagaev I, Berg O G, Hughes D, Andersson D I
Abstract excerpt
Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a...
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