Pathways of genetic adaptation: multistep origin of mutants under selection without induced mutagenesis in Salmonella enterica.

Abstract excerpt

In several bacterial systems, mutant cell populations plated on growth-restricting medium give rise to revertant colonies that accumulate over several days. One model suggests that nongrowing parent cells mutagenize their own genome and thereby create beneficial mutations (stress-induced mutagenesis). By this model, the first-order induction of new mutations in a nongrowing parent cell population leads to the...

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