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Article

Virulence of antibiotic-resistant Salmonella typhimurium.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998

Björkman J, Hughes D, Andersson D I

Abstract excerpt

We show that most Salmonella typhimurium mutants resistant to streptomycin, rifampicin, and nalidixic acid are avirulent in mice. Of seven resistant mutants examined, six were avirulent and one was similar to the wild type in competition experiments in mice. The avirulent-resistant mutants rapidly accumulated various types of compensatory mutations that restored virulence without concomitant loss of resistance....

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Identifiers

PMID: 9520473
DOI: 10.1073/pnas.95.7.3949
PMCID: PMC19943

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