Article
Pathoadaptive mutations in Salmonella enterica isolated after serial passage in mice.
PloS one - 1 Jan 2013
Koskiniemi Sanna, Gibbons Henry S, Sandegren Linus, Anwar Naeem, Ouellette Gary, Broomall Stacey, Karavis Mark, McGregor Paul, Liem Alvin, Fochler Ed, McNew Lauren, Rosenzweig Carolyn Nicole, Rhen Mikael, Skowronski Evan W, Andersson Dan I
Abstract excerpt
How pathogenic bacteria adapt and evolve in the complex and variable environment of the host remains a largely unresolved question. Here we have used whole genome sequencing of Salmonella enterica serovar Typhimurium LT2 populations serially passaged in mice to identify mutations that adapt bacteria to systemic growth in mice. We found unique pathoadaptive mutations in two global regulators, phoQ and stpA, which...
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