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Article

DNA methylation pattern in human zygotes and developing embryos

1 Dec 2004

Abstract excerpt

We report on observations of the global methylation/demethylation pattern of both pronuclei in human zygotes and in early embryos up to the blastocyst stage. Our results demonstrate that in about half of the zygotes examined the paternal chromatin was less methylated than the maternal chromatin. In the other half, both pronuclei exhibited the same intensity of labeling. The nuclei in developing embryos were...

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PMID: 15579587
DOI: 10.1530/rep.1.00217

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