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Article

DNA methylation state is preserved in the sperm-derived pronucleus of the pig zygote

1 Jan 2007

Abstract excerpt

DNA methylation reprogramming (DMR) during preimplantation development erases differentiation-associated, unessential epigenetic information accumulated during gametogenesis, and ultimately brings pluripotency to the resulting embryo. Two patterns of DMR of sperm-derived pronucleus have been reported in mammals. In the first, the male pronucleus is actively demethylated whereas in the second, the methylation...

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Share to Epigenetics and DNA Methylation
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PMID: 17939117
DOI: 10.1387/ijdb.072450yj

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