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Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes

3 Nov 2008

Abstract excerpt

BACKGROUND: In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zygotes. Such active DNA demethylation in the zygote has been documented for several mammalian species, including mouse, rat, pig, human and cow, but questioned to occur in rabbit. RESULTS: When...

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PMID: 19014417
DOI: 10.1186/1756-8935-1-8

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