Article
A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma.
Japanese journal of cancer research : Gann - 1 Nov 2000
Okimoto K, Kouchi M, Kikawa E, Toyosawa K, Koujitani T, Tanaka K, Matsuoka N, Sakurai J, Hino O
Abstract excerpt
A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan, and named the rising "Nihon" rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in...
Topics
- Animals
- Blotting, Northern
- Blotting, Southern
- Carcinoma, Renal Cell
- Crosses, Genetic
- Disease Models, Animal
- Female
- Genes, Dominant
- Genes, Tumor Suppressor
- Kidney Neoplasms
- Ligases
- Male
- Mutation
- Pedigree