Article
Prevalence of mutations of the NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn disease.
Scandinavian journal of gastroenterology - 1 Dec 2003
Mendoza J L, Murillo L S, Fernández L, Peña A S, Lana R, Urcelay E, Cruz-Santamaría D M, de la Concha E G, Díaz-Rubio M, García-Paredes J
Abstract excerpt
BACKGROUND: We assessed the prevalence of R702W, G908R, and L1007fs coding mutations in the NOD2/CARD15 gene and the genotype-phenotype relation in Spanish patients with Crohn disease. METHODS: A cohort of 204 unrelated patients with Crohn disease and 140 healthy controls were studied. The phenotype was established before commencement of genotyping. Genotyping of the R702W, G908R, and L1007fs gene polymorphisms...
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