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Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity

2 Dec 2004

Abstract excerpt

Metastatic malignant melanoma is an extremely aggressive cancer, with no currently viable therapy. 4-Allyl-2-methoxyphenol (eugenol) was tested for its ability to inhibit proliferation of melanoma cells. Eugenol but not its isomer, isoeugenol (2-methoxy-4-propenylphenol), was found to be a potent inhibitor of melanoma cell proliferation. In a B16 xenograft study, eugenol treatment produced a significant tumor...

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PMID: 15574415
DOI: 10.1074/jbc.m411429200

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