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Article

A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model

1 Aug 2008

Abstract excerpt

HLM006474 was identified using a computer-based virtual screen and the known crystal structure of the DNA-bound E2F4/DP2 heterodimer. Treatment of multiple cell lines with HLM006474 resulted in the loss of intracellular E2F4 DNA-binding activity as measured by electrophoretic mobility shift assay within hours. Overnight exposure to HLM006474 resulted in down-regulation of total E2F4 protein as well as known E2F...

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PMID: 18676853
DOI: 10.1158/0008-5472.can-08-0121

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