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Article

Dimethylfumarate Impairs Melanoma Growth and Metastasis

15 Dec 2006

Abstract excerpt

Dimethylfumarate (DMF) inhibits signals transmitted by Rel proteins and is used for the treatment of inflammatory skin diseases such as psoriasis, but potential effects of DMF on tumor progression have yet not been analyzed. We show that DMF reduced melanoma growth and metastasis in severe combined immunodeficient mouse models. To identify targets of DMF action, we analyzed mRNA expression in DMF-treated...

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PMID: 17178886
DOI: 10.1158/0008-5472.can-06-2397

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