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Article

Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells.

European journal of pharmacology - 5 Sept 2015

Tabolacci Claudio, Cordella Martina, Turcano Lorenzo, Rossi Stefania, Lentini Alessandro, Mariotti Sabrina, Nisini Roberto, Sette Giovanni, Eramo Adriana, Piredda Lucia, De Maria Ruggero, Facchiano Francesco, Beninati Simone

Abstract excerpt

Aim of this study was to extend the knowledge on the antineoplastic effect of aloe-emodin (AE), a natural hydroxyanthraquinone compound, both in metastatic human melanoma cell lines and in primary stem-like cells (melanospheres). Treatment with AE caused reduction of cell proliferation and induction of SK-MEL-28 and A375 cells differentiation, characterized by a marked increase of transamidating activity of...

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Source

Identifiers

PMID: 26048310
DOI: 10.1016/j.ejphar.2015.05.057

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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