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[Sensitivity comparison of DNA damage and repair capacity in TK6 and WTK1 cells].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 1 Nov 2004

Zhang Jian-qing, Zhang Li-shi, Wang Rui-shu

Abstract excerpt

OBJECTIVE: Explore the mechanisms of DNA damage and repair capacity in TK6 and WTK1 cells that are derived from the same parental cell line WI-L2 (tk+/+) human diploid lymphoblastoid cells but are different in their p53 gene status. METHODS: The TK6 and WTK1 cells treated with H2O2 were detected by single cell gel electrophoresis. Then a comparison was made on the comet cell rate, comet cell tail length and p53...

Topics

Cell Line
Comet Assay
DNA Damage
DNA Repair
Genes, p53
Humans
Hydrogen Peroxide
Lymphocytes
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15573749

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