Article
Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.
Molecular and cellular biology - 1 Dec 2004
Intine Robert V, Dundr Miroslav, Vassilev Alex, Schwartz Elena, Zhao Yingmin, Zhao Yingxin, Depamphilis Melvin L, Maraia Richard J
Abstract excerpt
La is a RNA-binding protein implicated in multiple pathways related to the production of tRNAs, ribosomal proteins, and other components of the translational machinery (D. J. Kenan and J. D. Keene, Nat. Struct. Mol. Biol. 11:303-305, 2004). While most La is phosphorylated and resides in the nucleoplasm, a fraction is in the nucleolus, the site of ribosome production, although the determinants of this localization...
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