Article
Two different combinations of RNA-binding domains determine the RNA binding specificity of nucleolin.
The Journal of biological chemistry - 27 Apr 2001
Ginisty H, Amalric F, Bouvet P
Abstract excerpt
Nucleolin is an abundant nucleolar protein involved in several steps of ribosome biogenesis. The protein is highly conserved through evolution and possesses four RNA-binding domains (RBD), which are likely to determine its RNA binding specificity. Previous studies have shown that nucleolin interacts with two different RNA targets. The first is a small stem-loop structure, the nucleolin recognition element (NRE),...
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