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Article

Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder.

Molecular systems biology - 1 Aug 2020

Stenström Lovisa, Mahdessian Diana, Gnann Christian, Cesnik Anthony J, Ouyang Wei, Leonetti Manuel D, Uhlén Mathias, Cuylen-Haering Sara, Thul Peter J, Lundberg Emma

Abstract excerpt

The nucleolus is essential for ribosome biogenesis and is involved in many other cellular functions. We performed a systematic spatiotemporal dissection of the human nucleolar proteome using confocal microscopy. In total, 1,318 nucleolar proteins were identified; 287 were localized to fibrillar components, and 157 were enriched along the nucleoplasmic border, indicating a potential fourth nucleolar...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32744794
DOI: 10.15252/msb.20209469
PMCID: PMC7397901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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