Article

A Novel Role for Nucleolin in Splice Site Selection

2020-12-03

Abstract excerpt

Latent 5’ splice sites are highly abundant in human introns, yet, are apparently not normally used. Splicing at most of these sites would incorporate in-frame stop codons generating nonsense mRNAs. Importantly, under stress and in cancer, splicing at latent sites is activated generating nonsense mRNAs from thousands of genes. Previous studies point to an unresolved RNA quality control mechanism that suppresses lat...

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Literature Corpus work: b35244d6-1ea5-5684-98dc-09ec3656d942
DOI: 10.1101/2020.12.02.402354

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