Article
Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.
The Journal of cell biology - 10 Jun 2002
Cakouros Dimitrios, Daish Tasman, Martin Damali, Baehrecke Eric H, Kumar Sharad
Abstract excerpt
The steroid hormone ecdysone regulates both cell differentiation and cell death during insect metamorphosis, by hierarchical transcriptional regulation of a number of genes, including the Broad-Complex (BR-C), the zinc finger family of transcription factors. These genes in turn regulate the transcription of a number of downstream genes. DRONC, a key apical caspase in Drosophila, is the only known caspase that is...
Topics
- Animals
- Apoptosis
- Caspases
- Cells, Cultured
- Dose-Response Relationship, Drug
- Drosophila
- Drosophila Proteins
- Ecdysone
- Embryo, Nonmammalian
- Enzyme Induction
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Enzymologic
- Metamorphosis, Biological