Article
Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos.
Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2013
Kim Soyoung, Ishidate Takao, Sharma Rita, Soto Martha C, Conte Darryl, Mello Craig C, Shirayama Masaki
Abstract excerpt
In early Caenorhabditis elegans embryos, the Wingless/int (Wnt)- and Src-signaling pathways function in parallel to induce both the division orientation of the endomesoderm (EMS) blastomere and the endoderm fate of the posterior EMS daughter cell, called E. Here, we show that, in addition to its role in endoderm specification, the β-catenin-related protein Worm armadillo 1 (WRM-1) also plays a role in controlling...
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