Article
IgM monomers accelerate disease manifestations in autoimmune-prone Fas-deficient mice.
Journal of autoimmunity - 1 Dec 2004
Youd Michele E, Luus Lia, Corley Ronald B
Abstract excerpt
The monomeric form of IgM, also known as low molecular weight IgM, is found in increased concentrations in patients chronically infected with a variety of viral and bacterial pathogens or suffering from various autoimmune diseases. Whether monomeric IgM contributes to the disease process, however, is not known. To address this question, transgenic mice were created that secreted elevated levels of IgM monomers....
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