Article
Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2000
Boes M, Schmidt T, Linkemann K, Beaudette B C, Marshak-Rothstein A, Chen J
Abstract excerpt
Individuals with systemic lupus erythematosus and rheumatoid arthritis are characterized by the presence of high levels of circulating IgM and IgG autoantibodies. Although IgG autoantibodies often are pathogenic, the role of IgM autoantibodies in autoimmune disease is not clear. Using mice that are unable to secrete IgM but are able to express surface IgM and IgD and to secrete other classes of immunoglobulins,...
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