Article
Mortality in patients with hypertension on angiotensin-I converting enzyme (ACE)-inhibitor treatment is influenced by the ACE insertion/deletion polymorphism.
Pharmacogenetics and genomics - 1 Feb 2005
Bleumink Gysèle S, Schut Anna F C, Sturkenboom Miriam C J M, van Duijn Cornelia M, Deckers Jaap W, Hofman Albert, Kingma J Herre, Witteman Jacqueline C M, Stricker Bruno H Ch
Abstract excerpt
BACKGROUND: The response to angiotensin-I converting enzyme (ACE)-inhibitor therapy is highly variable. Residual ACE activity during treatment, potentially modified by the ACE insertion/deletion (I/D) polymorphism, may explain part of this variability. We studied the possible interaction between ACE-inhibitor therapy in patients with hypertension and the ACE I/D polymorphism in incident heart failure and death....
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