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Article

Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia.

British journal of haematology - 1 Jun 1999

McLeod H L, Coulthard S, Thomas A E, Pritchard S C, King D J, Richards S M, Eden O B, Hall A G, Gibson B E

Abstract excerpt

The role of 6-mercaptopurine (6MP) in the treatment of childhood acute lymphoblastic leukaemia (ALL) is well established. However, the efficacy of 6MP is significantly influenced by inactivation by the polymorphic enzyme thiopurine methyltransferase (TPMT). In the general population 89-94% have high TPMT activity, 6-11% have intermediate activity, and approximately 0.3% have low activity. Individuals with...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 10354134
DOI: 10.1046/j.1365-2141.1999.01416.x

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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