Article
Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection.
Blood - 6 Oct 2011
Li Sha, Choi Hak-Jong, Felio Kyrie, Wang Chyung-Ru
Abstract excerpt
Group 1 CD1 (CD1a, -b, and -c) presents self and foreign lipid antigens to multiple T-cell subsets in humans. However, in the absence of a suitable animal model, the specific functions and developmental requirements of these T cells remain unknown. To study group 1 CD1-restricted T cells in vivo, we generated double transgenic mice (HJ1Tg/hCD1Tg) that express group 1 CD1 molecules in a similar pattern to that...
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